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Epstein-Barr virus-derived plasmids replicate only once per cell cycle and are not amplified after entry into cells

1 Jan 1991

Abstract excerpt

Some possible ways in which replication of plasmids containing the Epstein-Barr virus (EBV) plasmid maintenance origin, oriP, might be controlled were investigated. Virtually all plasmid molecules were found to replicate no more than once per cell cycle, whether replication was observed after stable introduction of the plasmids into cells by drug selection or during the first few cell divisions after introducing...

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Identifiers

PMID: 1845903
DOI: 10.1128/jvi.65.1.483-488.1991

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Epstein-Barr virus-derived plasmids replicate only once per cell cycle and are not amplified after entry into cellsPMID 1845903Read ↗

Establishment of an <i>oriP</i> Replicon Is Dependent upon an Infrequent, Epigenetic EventSemantic proximity Read ↗

Plasmid maintenance of derivatives of oriP of Epstein-Barr virusSemantic proximity Read ↗

Rep*: a viral element that can partially replace the origin of plasmid DNA synthesis of Epstein-Barr virus.Semantic proximity Read ↗

Initiation of DNA replication within oriP is dispensable for stable replication of the latent Epstein-Barr virus chromosome after infection of established cell lines.Semantic proximity Read ↗

The minimal replicator of Epstein-Barr virus oriP.Semantic proximity Read ↗

The plasmid replicon of Epstein–Barr virus: Mechanistic insights into efficient, licensed, extrachromosomal replication in human cellsSemantic proximity Read ↗

Sequence requirements of the Epstein-Barr virus latent origin of DNA replicationSemantic proximity Read ↗

Maintenance of Epstein–Barr virus (EBV) <i>oriP</i> -based episomes requires EBV-encoded nuclear antigen-1 chromosome-binding domains, which can be replaced by high-mobility group-I or histone H1Semantic proximity Read ↗

Genetic evidence that EBNA-1 is needed for efficient, stable latent infection by Epstein-Barr virus.Semantic proximity Read ↗

Metaphase Chromosome Tethering Is Necessary for the DNA Synthesis and Maintenance of <i>oriP</i> Plasmids but Is Insufficient for Transcription Activation by Epstein-Barr Nuclear Antigen 1Semantic proximity Read ↗

EBNA1 can link the enhancer element to the initiator element of the Epstein-Barr virus plasmid origin of DNA replicationSemantic proximity Read ↗

Telomere Repeat Binding Factors TRF1, TRF2, and hRAP1 Modulate Replication of Epstein-Barr Virus OriPSemantic proximity Read ↗

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