Article
Episomal and integrated copies of Epstein-Barr virus coexist in Burkitt lymphoma cell lines.
Journal of virology - 1 Mar 1993
Delecluse H J, Bartnizke S, Hammerschmidt W, Bullerdiek J, Bornkamm G W
Abstract excerpt
The Epstein-Barr virus genome is present in more than 95% of the African cases of Burkitt lymphoma. In this tumor, the viral genome is usually maintained in multiple episomal copies. Viral integration has been described only for Namalwa, a cell line lacking episomes. In this study, we have addres...
Topics
- Africa
- B-Lymphocytes
- Burkitt Lymphoma
- Chromosome Banding
- Chromosomes, Human
- DNA Probes
- DNA, Viral
- Genetic Variation
- Herpesvirus 4, Human
- Humans
- In Situ Hybridization
- Karyotyping
- Metaphase
- Plasmids
- Serial Passage
- Tumor Cells, Cultured
- Virus Integration