Article
Episomal and integrated copies of Epstein-Barr virus coexist in Burkitt lymphoma cell lines.
Journal of virology - 1 Mar 1993
Delecluse H J, Bartnizke S, Hammerschmidt W, Bullerdiek J, Bornkamm G W
Abstract excerpt
The Epstein-Barr virus genome is present in more than 95% of the African cases of Burkitt lymphoma. In this tumor, the viral genome is usually maintained in multiple episomal copies. Viral integration has been described only for Namalwa, a cell line lacking episomes. In this study, we have addressed the question of whether integrated and episomal copies can coexist in Burkitt lymphoma cells. Gel electrophoresis...
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