Intrachromosomal recombination mediated by papovavirus large T antigens.

doi:10.1128/JVI.64.6.2958-2966.1990

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Article

Intrachromosomal recombination mediated by papovavirus large T antigens.

Journal of virology - 1 Jun 1990

St-Onge L, Bouchard L, Laurent S, Bastin M

Abstract excerpt

To investigate the mechanism by which the large T antigen (T-Ag) of polyomavirus and simian virus 40 can promote recombination in mammalian cells, we analyzed homologous recombination events occurring between two defective copies of the polyomavirus middle T (pmt) oncogene lying in close proximit...

Topics

Animals
Antigens, Polyomavirus Transforming
Blotting, Southern
Cell Line
Chromosomes
DNA Replication
DNA Transposable Elements
Defective Viruses
Mutation
Oncogenes
Plasmids
Polyomavirus
Promoter Regions, Genetic
Recombination, Genetic
Restriction Mapping
Simian virus 40

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