Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanisms of translational deregulation in human tumors and therapeutic intervention strategies.

Oncogene - 6 Sept 2007

Bilanges B, Stokoe D

Abstract excerpt

Analysis of the recurrent genetic aberrations present in human tumors provides insight into how normal cells escape appropriate proliferation and survival cues. Commonly mutated genes encode proteins that monitor DNA damage (e.g., p53), proteins that regulate the cell cycle (such as Rb), and proteins that regulate signal transduction pathways (such as APC, PTEN and Ras). Analysis of the relevant targets and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Expression Regulation, Neoplastic
Share to Neoplasm Proteins
Share to Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Oncogenes

Share to Protein Biosynthesis

Share to Ribosomes

Share to RNA, Messenger

Share to Suppression, Genetic

Source

Identifiers

PMID: 17404576
DOI: 10.1038/sj.onc.1210431

Genes

APC
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanisms of translational deregulation in human tumors and therapeutic intervention strategies.PMID 17404576Read ↗

Translational control in cancer etiology.Semantic proximity Read ↗

The cancerous translation apparatus.Semantic proximity Read ↗

Translation initiation in cancer: a novel target for therapy.Semantic proximity Read ↗

Translational Regulation of Cancer Metastasis.Semantic proximity Read ↗

Cancer Plasticity: The Role of mRNA Translation.Semantic proximity Read ↗

Targeting Protein Synthesis in Colorectal CancerSemantic proximity Read ↗

p53 induces transcriptional and translational programs to suppress cell proliferation and growthSemantic proximity Read ↗

Translational control of aberrant stress responses as a hallmark of cancer.Semantic proximity Read ↗

Oncogenic signaling pathways and deregulated target genes.Semantic proximity Read ↗

Translational Upregulation of an Individual p21Cip1 Transcript Variant by GCN2 Regulates Cell Proliferation and Survival under Nutrient StressSemantic proximity Read ↗

Lost in translation: dysregulation of cap-dependent translation and cancer.Semantic proximity Read ↗

Cross-talk between protein synthesis, energy metabolism and autophagy in cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.