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Article

Translational Regulation of Cancer Metastasis.

Cancer research - 1 Feb 2021

Micalizzi Douglas S, Ebright Richard Y, Haber Daniel A, Maheswaran Shyamala

Abstract excerpt

Deregulation of the mRNA translational process has been observed during tumorigenesis. However, recent findings have shown that deregulation of translation also contributes specifically to cancer cell spread. During metastasis, cancer cells undergo changes in cellular state, permitting the acquisition of features necessary for cell survival, dissemination, and outgrowth. In addition, metastatic cells respond to...

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Source

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Identifiers

PMID: 33479028
DOI: 10.1158/0008-5472.CAN-20-2720
PMCID: PMC7854484

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