Article
Development of admixture mapping panels for African Americans from commercial high-density SNP arrays.
BMC genomics - 5 Jul 2010
Chen Guanjie, Shriner Daniel, Zhou Jie, Doumatey Ayo, Huang Hanxia, Gerry Norman P, Herbert Alan, Christman Michael F, Chen Yuanxiu, Dunston Georgia M, Faruque Mezbah U, Rotimi Charles N, Adeyemo Adebowale
Abstract excerpt
BACKGROUND: Admixture mapping is a powerful approach for identifying genetic variants involved in human disease that exploits the unique genomic structure in recently admixed populations. To use existing published panels of ancestry-informative markers (AIMs) for admixture mapping, markers have to be genotyped de novo for each admixed study sample and samples representing the ancestral parental populations. The...
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