Large-scale admixture mapping in the All of Us Research Program improves the characterization of cross-population phenotypic differences.

doi:10.1038/s41467-026-75515-6

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Article

Large-scale admixture mapping in the All of Us Research Program improves the characterization of cross-population phenotypic differences.

Nature communications - 12 Aug 2026

Mandla Ravi, Shi Zhuozheng, Hou Kangcheng, Wang Ying, Mies Georgia, Aw Alan J, Cullina Sinead, Kenny Eimear, Mathieson Iain, Atkinson Elizabeth G, Martin Alicia R, Pasaniuc Bogdan

Abstract excerpt

Admixed individuals have been understudied in medical research largely due to their complex genetic ancestries. However, the consideration of admixture can identify ancestry-enriched genetic associations, delineating genetic underpinnings of cross-population phenotypic variation. Here, we performed admixture mapping in individuals with inferred admixture from African and European populations (N = 48,921). Across...

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Topics

Humans
Phenotype
Haplotypes
Polymorphism, Single Nucleotide
Chromosome Mapping

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

White People

European People

Genetics, Population

African People

Black People

Genome-Wide Association Study

Quantitative Trait Loci

Source

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Identifiers

PMID: 42716946
DOI: 10.1038/s41467-026-75515-6
PMCID: PMC13558699

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