Article
Imputation-Aware Tag SNP Selection To Improve Power for Large-Scale, Multi-ethnic Association Studies.
G3 (Bethesda, Md.) - 3 Oct 2018
Wojcik Genevieve L, Fuchsberger Christian, Taliun Daniel, Welch Ryan, Martin Alicia R, Shringarpure Suyash, Carlson Christopher S, Abecasis Goncalo, Kang Hyun Min, Boehnke Michael, Bustamante Carlos D, Gignoux Christopher R, Kenny Eimear E
Abstract excerpt
The emergence of very large cohorts in genomic research has facilitated a focus on genotype-imputation strategies to power rare variant association. These strategies have benefited from improvements in imputation methods and association tests, however little attention has been paid to ways in which array design can increase rare variant association power. Therefore, we developed a novel framework to select tag...
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