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Article

Mili, a mammalian member of piwi family gene, is essential for spermatogenesis.

Development (Cambridge, England) - 1 Feb 2004

Kuramochi-Miyagawa Satomi, Kimura Tohru, Ijiri Takashi W, Isobe Taku, Asada Noriko, Fujita Yukiko, Ikawa Masahito, Iwai Naomi, Okabe Masaru, Deng Wei, Lin Haifan, Matsuda Yoichi, Nakano Toru

Abstract excerpt

The piwi family genes, which are defined by conserved PAZ and Piwi domains, play important roles in stem cell self-renewal, RNA silencing, and translational regulation in various organisms. To reveal the function of the mammalian homolog of piwi, we produced and analyzed mice with targeted mutati...

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Identifiers

PMID: 14736746
DOI: 10.1242/dev.00973

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14736746-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Research trail→

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Mili, a mammalian member of piwi family gene, is essential for spermatogenesis.PMID 14736746Read ↗

Pinpointing the expression of piRNAs and function of the PIWI protein subfamily during spermatogenesis in the mouse.Semantic proximity Read ↗

Associations between PIWI proteins and TDRD1/MTR-1 are critical for integrated subcellular localization in murine male germ cells.Semantic proximity Read ↗

piRNAs and their involvement in male germline development in mice.Semantic proximity Read ↗

Male factor infertility: Piwi, Hiwi, Miwi: essential genes for effective spermiogenesis.Semantic proximity Read ↗

The RNA-binding protein Musashi is required intrinsically to maintain stem cell identity.Semantic proximity Read ↗

PNLDC1, mouse pre-piRNA Trimmer, is required for meiotic and post-meiotic male germ cell development.Semantic proximity Read ↗

Ubiquitination-Deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange during Spermiogenesis.Semantic proximity Read ↗

An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes.Semantic proximity Read ↗

MOV10L1 is necessary for protection of spermatocytes against retrotransposons by Piwi-interacting RNAs.Semantic proximity Read ↗

Disruption of the murine PIASx gene results in reduced testis weightSemantic proximity Read ↗

MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline.Semantic proximity Read ↗

PNLDC1 catalysis and postnatal germline function are required for piRNA trimming, LINE1 silencing, and spermatogenesis in miceSemantic proximity Read ↗

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