Article
Mili, a mammalian member of piwi family gene, is essential for spermatogenesis.
Development (Cambridge, England) - 1 Feb 2004
Kuramochi-Miyagawa Satomi, Kimura Tohru, Ijiri Takashi W, Isobe Taku, Asada Noriko, Fujita Yukiko, Ikawa Masahito, Iwai Naomi, Okabe Masaru, Deng Wei, Lin Haifan, Matsuda Yoichi, Nakano Toru
Abstract excerpt
The piwi family genes, which are defined by conserved PAZ and Piwi domains, play important roles in stem cell self-renewal, RNA silencing, and translational regulation in various organisms. To reveal the function of the mammalian homolog of piwi, we produced and analyzed mice with targeted mutations in the Mili gene, which is one of three mouse homologs of piwi. Spermatogenesis in the MILI-null mice was blocked...
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