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Article

MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline.

Developmental cell - 1 Apr 2007

Carmell Michelle A, Girard Angélique, van de Kant Henk J G, Bourc'his Deborah, Bestor Timothy H, de Rooij Dirk G, Hannon Gregory J

Abstract excerpt

Small RNAs associate with Argonaute proteins and serve as sequence-specific guides for regulation of mRNA stability, productive translation, chromatin organization, and genome structure. In animals, the Argonaute superfamily segregates into two clades. The Argonaute clade acts in RNAi and in microRNA-mediated gene regulation in partnership with 21-22 nt RNAs. The Piwi clade, and their 26-30 nt piRNA partners,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17395546
DOI: 10.1016/j.devcel.2007.03.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline.PMID 17395546Read ↗

piRNAs and their involvement in male germline development in mice.Semantic proximity Read ↗

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AGO4 regulates entry into meiosis and influences silencing of sex chromosomes in the male mouse germline.Semantic proximity Read ↗

Inherited defects of piRNA biogenesis cause transposon de-repression, impaired spermatogenesis, and human male infertilitySemantic proximity Read ↗

An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes.Semantic proximity Read ↗

RNF17 blocks promiscuous activity of PIWI proteins in mouse testes.Semantic proximity Read ↗

The roles of microRNAs and siRNAs in mammalian spermatogenesisSemantic proximity Read ↗

Pinpointing the expression of piRNAs and function of the PIWI protein subfamily during spermatogenesis in the mouse.Semantic proximity Read ↗

MOV10L1 is necessary for protection of spermatocytes against retrotransposons by Piwi-interacting RNAs.Semantic proximity Read ↗

Functional Investigation of a Novel PIWIL4 Mutation in Nonobstructive Azoospermia During the First Wave of Spermatogenesis.Semantic proximity Read ↗

MicroRNA Biogenesis Is Required for Mouse Primordial Germ Cell Development and SpermatogenesisSemantic proximity Read ↗

Mouse maelstrom, a component of nuage, is essential for spermatogenesis and transposon repression in meiosis.Semantic proximity Read ↗

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