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Article

TGFβ signaling and congenital heart disease: Insights from mouse studies

28 Apr 2011

Abstract excerpt

Transforming growth factor β (TGFβ) regulates one of the major signaling pathways that control tissue morphogenesis. In vitro experiments using heart explants indicated the importance of this signaling pathway for the generation of cushion mesenchymal cells, which ultimately contribute to the valves and septa of the mature heart. Recent advances in mouse genetics have enabled in vivo investigation into the roles...

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PMID: 21538815
DOI: 10.1002/bdra.20794

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