Article
Expression patterns of Tgfbeta1-3 associate with myocardialisation of the outflow tract and the development of the epicardium and the fibrous heart skeleton.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jul 2003
Molin Daniël G M, Bartram Ulrike, Van der Heiden Kim, Van Iperen Liesbeth, Speer Christian P, Hierck Beerend P, Poelmann Robert E, Gittenberger-de-Groot Adriana C
Abstract excerpt
Transforming growth factor-beta (Tgfbeta) is essential for normal embryogenesis. The cardiac phenotypes obtained after knockout of each of the three mammalian isoforms suggest different roles during morphogenesis. We studied cardiovascular expression of Tgfbeta1-3 in parallel tissue sections of normal mouse embryos from 9.5 to 15.5 days post coitum (dpc) by using radioactive in situ hybridisation. The Tgfbeta...
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