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Article

Wnt/β-catenin signaling enables developmental transitions during valvulogenesis

1 Jan 2016

Abstract excerpt

Heart valve development proceeds through coordinated steps by which endocardial cushions (ECs) form thin, elongated and stratified valves. Wnt signaling and its canonical effector β-catenin are proposed to contribute to endocardial-to-mesenchymal transformation (EMT) through postnatal steps of valvulogenesis. However, genetic redundancy and lethality have made it challenging to define specific roles of the...

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PMID: 26893350
DOI: 10.1242/dev.130575

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