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Article

Ubiquitin-dependent control of class II MHC localization is dispensable for antigen presentation and antibody production.

PloS one - 20 Apr 2011

McGehee Annette M, Strijbis Karin, Guillen Eduardo, Eng Thomas, Kirak Oktay, Ploegh Hidde L

Abstract excerpt

Controlled localization of class II MHC molecules is essential for proper class II MHC-restricted antigen presentation and the subsequent initiation of an adaptive immune response. Ubiquitination of class II MHC molecules on cytosolic lysine (K225) of the β-chain has been shown to affect localization of the complex. We generated mice in which the endogenous β-chain locus is replaced with a GFP tagged mutant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21533087
DOI: 10.1371/journal.pone.0018817
PMCID: PMC3080378

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