Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ubiquitylation and developmental regulation of invariant surface protein expression in trypanosomes.

Eukaryotic cell - 1 Jul 2011

Leung Ka Fai, Riley Fay S, Carrington Mark, Field Mark C

Abstract excerpt

The cell surface of Trypanosoma brucei is dominated by the glycosylphosphatidylinositol-anchored variant surface glycoprotein (VSG), which is essential for immune evasion. VSG biosynthesis, trafficking, and turnover are well documented, but trans-membrane domain (TMD) proteins, including the invariant surface glycoproteins (ISGs), are less well characterized. Internalization and degradation of ISG65 depend on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endocytosis
Share to Glycosylphosphatidylinositols
Share to Lysine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Membrane Glycoproteins

Share to Protein Processing, Post-Translational

Share to Protozoan Proteins

Share to Trypanosoma brucei brucei

Share to Ubiquitination

Source

Open in PubMed Open full text

Identifiers

PMID: 21571921
DOI: 10.1128/EC.05012-11
PMCID: PMC3147413

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ubiquitylation and developmental regulation of invariant surface protein expression in trypanosomes.PMID 21571921Read ↗

<i>Trypanosoma cruzi</i> VDU deubiquitinase mediates surface protein trafficking and infectivitySemantic proximity Read ↗

To the Surface and Back: Exo- and Endocytic Pathways in Trypanosoma bruceiSemantic proximity Read ↗

Ubiquitin and ubiquitin-like conjugation systems in trypanosomatidsSemantic proximity Read ↗

Architecture of a Host–Parasite Interface: Complex Targeting Mechanisms Revealed Through ProteomicsSemantic proximity Read ↗

Differential endocytic functions of Trypanosoma brucei Rab5 isoforms reveal a glycosylphosphatidylinositol-specific endosomal pathway.Semantic proximity Read ↗

Cell Surface Proteomics Provides Insight into Stage-Specific Remodeling of the Host-Parasite Interface in Trypanosoma brucei*Semantic proximity Read ↗

The trypanosome Variant Surface Glycoprotein mRNA is stabilized by an essential unconventional RNA-binding proteinSemantic proximity Read ↗

Orientia tsutsugamushi OtDUB Is Expressed and Interacts with Adaptor Protein Complexes during InfectionSemantic proximity Read ↗

Monoallelic antigen expression in trypanosomes requires a stage-specific transcription activatorSemantic proximity Read ↗

PSSA-2, a membrane-spanning phosphoprotein of Trypanosoma brucei, is required for efficient maturation of infection.Semantic proximity Read ↗

An Apicoplast Localized Ubiquitylation System Is Required for the Import of Nuclear-encoded Plastid ProteinsSemantic proximity Read ↗

The Ubiquitin Proteome of Toxoplasma gondii Reveals Roles for Protein Ubiquitination in Cell-Cycle TransitionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.