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Article

K33-linked polyubiquitination of T cell receptor-zeta regulates proteolysis-independent T cell signaling.

Immunity - 23 Jul 2010

Huang Haining, Jeon Myung-Shin, Liao Lujian, Yang Chun, Elly Chris, Yates John R, Liu Yun-Cai

Abstract excerpt

Tagging the cell surface receptor with ubiquitin is believed to provide a signal for the endocytic pathway. E3 ubiquitin ligases such as Cbl-b and Itch have been implicated in T cell activation and tolerance induction. However, the underlying mechanisms remain unclear. We describe that in mice deficient in the E3 ubiquitin ligases Cbl-b and Itch, T cell activation was augmented, accompanied by spontaneous...

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Identifiers

PMID: 20637659
DOI: 10.1016/j.immuni.2010.07.002
PMCID: PMC2927827

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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