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Article

Dissecting MHC class II export, B cell maturation, and DM stability defects in invariant chain mutant mice.

Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2004

Koonce Chad H, Bikoff Elizabeth K

Abstract excerpt

Invariant (Ii) chain loss causes defective class II export, B cell maturation, and reduced DM stability. In this study, we compare Ii chain and class II mutant mouse phenotypes to dissect these disturbances. The present results demonstrate that ER retention of alphabeta complexes, and not beta-ch...

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Identifiers

PMID: 15322189
DOI: 10.4049/jimmunol.173.5.3271

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15322189-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Dissecting MHC class II export, B cell maturation, and DM stability defects in invariant chain mutant mice.PMID 15322189Read ↗

Posttranslational regulation of I-Ed by affinity for CLIP.Semantic proximity Read ↗

Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression.Semantic proximity Read ↗

Distinct peptide loading pathways for MHC class II molecules associated with alternative Ii chain isoforms.Semantic proximity Read ↗

DM-mediated release of a naturally occurring invariant chain degradation intermediate from MHC class II molecules.Semantic proximity Read ↗

Ubiquitin-dependent control of class II MHC localization is dispensable for antigen presentation and antibody production.Semantic proximity Read ↗

Relaxed DM requirements during class II peptide loading and CD4+ T cell maturation in BALB/c mice.Semantic proximity Read ↗

Intracellular transport of MHC class II and associated invariant chain in antigen presenting cells from AP-3-deficient mocha mice.Semantic proximity Read ↗

Antigen presentation and assembly by mouse I-Ak class II molecules in human APC containing deleted or mutated HLA DM genes.Semantic proximity Read ↗

Identification of residues in the class II-associated Ii peptide (CLIP) region of invariant chain that affect efficiency of MHC class II-mediated antigen presentation in an allele-dependent manner.Semantic proximity Read ↗

Class II-associated invariant chain peptide-independent binding of invariant chain to class II MHC molecules.Semantic proximity Read ↗

Evidence that binding site occupancy is necessary and sufficient for effective major histocompatibility complex (MHC) class II transport through the secretory pathway redefines the primary function of class II-associated invariant chain peptides (CLIP).Semantic proximity Read ↗

An altered invariant chain protein with an antigenic peptide in place of CLIP forms SDS-stable complexes with class II alphabeta dimers and facilitates highly efficient peptide loading.Semantic proximity Read ↗

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