Article
Genetic variation in PNPLA3 (adiponutrin) confers sensitivity to weight loss-induced decrease in liver fat in humans.
The American journal of clinical nutrition - 1 Jul 2011
Sevastianova Ksenia, Kotronen Anna, Gastaldelli Amalia, Perttilä Julia, Hakkarainen Antti, Lundbom Jesper, Suojanen Laura, Orho-Melander Marju, Lundbom Nina, Ferrannini Eleuterio, Rissanen Aila, Olkkonen Vesa M, Yki-Järvinen Hannele
Abstract excerpt
BACKGROUND: The rs738409 C→G single nucleotide polymorphism in the patatin-like phospholipase domain-containing 3 (PNPLA3; adiponutrin) leads to a missense mutation (I148M), which is associated with increased liver fat but not insulin resistance. The I148M mutation impedes triglyceride hydrolysis in vitro, and its carriers have an increased risk of developing severe liver disease. OBJECTIVE: We explored whether...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.