Article
A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans.
Diabetologia - 1 Jun 2009
Kotronen A, Johansson L E, Johansson L M, Roos C, Westerbacka J, Hamsten A, Bergholm R, Arkkila P, Arola J, Kiviluoto T, Fisher R M, Ehrenborg E, Orho-Melander M, Ridderstråle M, Groop L, Yki-Järvinen H
Abstract excerpt
AIMS/HYPOTHESIS: It has recently been suggested that the rs738409 G allele in PNPLA3, which encodes adiponutrin, is strongly associated with increased liver fat content in three different ethnic groups. The aims of the present study were as follows: (1) to try to replicate these findings in European individuals with quantitative measures of hepatic fat content; (2) to study whether the polymorphism influences...
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