A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents.

doi:10.1002/hep.23832

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Article

A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents.

Hepatology (Baltimore, Md.) - 1 Oct 2010

Santoro Nicola, Kursawe Romy, D'Adamo Ebe, Dykas Daniel J, Zhang Clarence K, Bale Allen E, Calí Anna M, Narayan Deepak, Shaw Melissa M, Pierpont Bridget, Savoye Mary, Lartaud Derek, Eldrich Samuel, Cushman Samuel W, Zhao Hongyu, Shulman Gerald I, Caprio Sonia

Abstract excerpt

UNLABELLED: The genetic factors associated with susceptibility to nonalcoholic fatty liver disease (NAFLD) in pediatric obesity remain largely unknown. Recently, a nonsynonymous single-nucleotide polymorphism (rs738409), in the patatin-like phospholipase 3 gene (PNPLA3) has been associated with h...

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Identifiers

PMID: 20803499
DOI: 10.1002/hep.23832
PMCID: PMC3221304

Genes

PNPLA3
ACACA
LEP
PNPLA2
SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20803499-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents.PMID 20803499Read ↗

I148M patatin-like phospholipase domain-containing 3 gene variant and severity of pediatric nonalcoholic fatty liver disease.Semantic proximity Read ↗

Unravelling the pathogenesis of fatty liver disease: patatin-like phospholipase domain-containing 3 protein.Semantic proximity Read ↗

Effects of PNPLA3 on liver fat and metabolic profile in Hispanic children and adolescents.Semantic proximity Read ↗

Genetic variation in the patatin-like phospholipase domain-containing protein-3 (PNPLA-3) gene in Asian Indians with nonalcoholic fatty liver disease.Semantic proximity Read ↗

Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene.Semantic proximity Read ↗

Effect of the patatin-like phospholipase domain containing 3 gene (PNPLA3) I148M polymorphism on the risk and severity of nonalcoholic fatty liver disease and metabolic syndromes: A meta-analysis of paediatric and adolescent individuals.Semantic proximity Read ↗

Update on nonalcoholic fatty liver disease: genes involved in nonalcoholic fatty liver disease and associated inflammation.Semantic proximity Read ↗

I148M variant of PNPLA3 increases the susceptibility to non-alcoholic fatty liver disease caused by obesity and metabolic disorders.Semantic proximity Read ↗

Patatin-like phospholipase 3 (rs738409) gene polymorphism is associated with increased liver enzymes in obese adolescents and metabolic syndrome in all ages.Semantic proximity Read ↗

Hepatic fat accumulation is modulated by the interaction between the rs738409 variant in the PNPLA3 gene and the dietary omega6/omega3 PUFA intake.Semantic proximity Read ↗

A gene variant of PNPLA3, but not of APOC3, is associated with histological parameters of NAFLD in an obese population.Semantic proximity Read ↗

The rs2294918 E434K variant modulates patatin-like phospholipase domain-containing 3 expression and liver damage.Semantic proximity Read ↗

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