Article
A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents.
Hepatology (Baltimore, Md.) - 1 Oct 2010
Santoro Nicola, Kursawe Romy, D'Adamo Ebe, Dykas Daniel J, Zhang Clarence K, Bale Allen E, Calí Anna M, Narayan Deepak, Shaw Melissa M, Pierpont Bridget, Savoye Mary, Lartaud Derek, Eldrich Samuel, Cushman Samuel W, Zhao Hongyu, Shulman Gerald I, Caprio Sonia
Abstract excerpt
UNLABELLED: The genetic factors associated with susceptibility to nonalcoholic fatty liver disease (NAFLD) in pediatric obesity remain largely unknown. Recently, a nonsynonymous single-nucleotide polymorphism (rs738409), in the patatin-like phospholipase 3 gene (PNPLA3) has been associated with hepatic steatosis in adults. In a multiethnic group of 85 obese youths, we genotyped the PNLPA3 single-nucleotide...
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