Article
I148M variant of PNPLA3 increases the susceptibility to non-alcoholic fatty liver disease caused by obesity and metabolic disorders.
Alimentary pharmacology & therapeutics - 1 Mar 2016
Xia M-F, Ling Y, Bian H, Lin H-D, Yan H-M, Chang X-X, Li X-M, Ma H, Wang D, Zhang L-S, Wang S-S, Wu B-J, He W-Y, Zhao N-Q, Gao X
Abstract excerpt
BACKGROUND: The patatin-like phospholipase 3 (PNPLA3) rs738409 gene polymorphism is an important genetic determinant of non-alcoholic fatty liver disease (NAFLD). However, the associations between liver fat and metabolic traits in rs738409 G allele carriers and the allelic influence on this association have not been fully studied. AIM: To investigate the influence of the PNPLA3 gene polymorphism on the...
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