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Article

Weight loss allows the dissection of the interaction between abdominal fat and PNPLA3 (adiponutrin) in the liver damage of obese children

8 Jul 2013

Abstract excerpt

In the patatin-like phospholipase domain-containing 3 gene (PNPLA3), there is a polymorphism named rs738409, which encodes for the adiponutrin I148M variant and is a genetic determinant of liver fat and non-alcoholic fatty liver disease (NAFLD).

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Identifiers

PMID: 23845393
DOI: 10.1016/j.jhep.2013.06.027

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Research trail→

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Weight loss allows the dissection of the interaction between abdominal fat and PNPLA3 (adiponutrin) in the liver damage of obese childrenPMID 23845393Read ↗

The association of PNPLA3 variants with liver enzymes in childhood obesity is driven by the interaction with abdominal fat.Semantic proximity Read ↗

The PNPLA3 I148M variant and chronic liver disease: When a genetic mutation meets nutrientsSemantic proximity Read ↗

Unravelling the pathogenesis of fatty liver disease: patatin-like phospholipase domain-containing 3 protein.Semantic proximity Read ↗

Research progress, challenges and perspectives on PNPLA3 and its variants in Liver DiseasesSemantic proximity Read ↗

PNPLA3 I148M variant in nonalcoholic fatty liver disease: demographic and ethnic characteristics and the role of the variant in nonalcoholic fatty liver fibrosis.Semantic proximity Read ↗

A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents.Semantic proximity Read ↗

PNPLA3 rs738409 underlies treatment response in nonalcoholic fatty liver diseaseSemantic proximity Read ↗

Association of rs738409 Polymorphism in Adiponutrin Gene with Liver Steatosis and Atherosclerosis Risk Factors in Greek Children and Adolescents.Semantic proximity Read ↗

Genetic variation in PNPLA3 (adiponutrin) confers sensitivity to weight loss-induced decrease in liver fat in humans.Semantic proximity Read ↗

Patatin-like phospholipase 3 (rs738409) gene polymorphism is associated with increased liver enzymes in obese adolescents and metabolic syndrome in all ages.Semantic proximity Read ↗

I148M variant of PNPLA3 increases the susceptibility to non-alcoholic fatty liver disease caused by obesity and metabolic disorders.Semantic proximity Read ↗

PNPLA3 I148M Polymorphism in Patients with Nonalcoholic Fatty Liver Disease, Obesity and Prediabetes.Semantic proximity Read ↗

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