PNPLA3 gene variation modulates diet-induced improvement in liver lipid content in type 2 diabetes.

doi:10.1016/j.clnu.2025.02.032

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Article

PNPLA3 gene variation modulates diet-induced improvement in liver lipid content in type 2 diabetes.

Clinical nutrition (Edinburgh, Scotland) - 1 May 2025

Pafili Kalliopi, Zaharia Oana-Patricia, Strassburger Klaus, Knebel Birgit, Herder Christian, Huttasch Maximilian, Karusheva Yanislava, Kabisch Stefan, Strom Alexander, Nowotny Bettina, Szendroedi Julia, Roden Michael

Abstract excerpt

BACKGROUND&AIMS: Lifestyle-induced weight reduction remains crucial for managing type 2 diabetes and steatotic liver disease, but its effectiveness varies. We postulated that the G allele in the rs738409 single nucleotide polymorphism within patatin-like phospholipase domain-containing protein 3 (PNPLA3), which associates with metabolic dysfunction-associated steatotic liver disease, also modulates diet-related...

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PMID: 40090039
DOI: 10.1016/j.clnu.2025.02.032

Genes

PNPLA3

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