Article

The PNPLA3 I148M variant and chronic liver disease: When a genetic mutation meets nutrients

2014-09-01

Abstract excerpt

The isoleucine to methionine substitution at position 148 in the patatin-like phospholipase domain containing 3 protein (PNPLA3; I148M variant, rs738409) is associated with liver fat accumulation and an increased risk of chronic liver disease ranging from hepatitis to hepatocellular carcinoma. This review discusses the interaction between the PNPLA3 I148M variant and obesity/intake of specific nutrients in determi...

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Literature Corpus work: a06a8e8a-e596-537c-bf91-4da557366748
DOI: 10.1016/j.foodres.2014.01.055

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