The rs2294918 E434K variant modulates patatin-like phospholipase domain-containing 3 expression and liver damage.

doi:10.1002/hep.28370

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Article

The rs2294918 E434K variant modulates patatin-like phospholipase domain-containing 3 expression and liver damage.

Hepatology (Baltimore, Md.) - 1 Mar 2016

Donati Benedetta, Motta Benedetta Maria, Pingitore Piero, Meroni Marica, Pietrelli Alessandro, Alisi Anna, Petta Salvatore, Xing Chao, Dongiovanni Paola, del Menico Benedetta, Rametta Raffaela, Mancina Rosellina Margherita, Badiali Sara, Fracanzani Anna Ludovica, Craxì Antonio, Fargion Silvia, Nobili Valerio, Romeo Stefano, Valenti Luca

Abstract excerpt

UNLABELLED: The patatin-like phosholipase domain-containing 3 (PNPLA3) rs738409 polymorphism (I148M) is a major determinant of hepatic fat and predisposes to the full spectrum of liver damage in nonalcoholic fatty liver disease (NAFLD). The aim of this study was to evaluate whether additional PNPLA3 coding variants contribute to NAFLD susceptibility, first in individuals with contrasting phenotypes (with...

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Identifiers

PMID: 26605757
DOI: 10.1002/hep.28370

Genes

PNPLA3

Variants

rs738409

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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