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Article

Hip osteoarthritis susceptibility is associated with IL1B -511(G>A) and IL1 RN (VNTR) genotypic polymorphisms in Croatian Caucasian population.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Aug 2011

Jotanovic Zdravko, Etokebe Godfrey E, Mihelic Radovan, Heiland Kårvatn Marikken, Mulac-Jericevic Biserka, Tijanic Tamara, Balen Sanja, Sestan Branko, Dembic Zlatko

Abstract excerpt

Among the predisposing factors to osteoarthritis (OA), a frequent destructive joint disease, is the complex genetic heritage including the interleukin-1 family members like the IL1β (IL1B) and the IL1 receptor antagonist (IL1RN) genes. The aim of this study was to investigate allelic and genotypic frequencies of the IL1B gene single nucleotide polymorphism (SNP) at -511(G>A) and the variable number tandem repeat...

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PMID: 21671260
DOI: 10.1002/jor.21378

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