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Article

MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome

26 Apr 2011

Abstract excerpt

MLL encodes a histone methyltransferase that is critical in maintaining gene expression during embryonic development and hematopoiesis. 11q23 translocations result in the formation of chimeric MLL fusion proteins that act as potent drivers of acute leukemia. However, it remains unclear what portion of the leukemic genome is under the direct control of MLL fusions. By comparing patient-derived leukemic cell lines,...

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PMID: 21518926
DOI: 10.1182/blood-2010-12-324699

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