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Article

c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis

21 Jan 2010

Abstract excerpt

Mixed-lineage leukemia (MLL) is a proto-oncogene frequently involved in chromosomal translocations associated with acute leukemia. These chromosomal translocations commonly result in MLL fusion proteins that dysregulate transcription. Recent data suggest that the MYB proto-oncogene, which is an important regulator of hematopoietic cell development, has a role in leukemogenesis driven by the MLL-ENL fusion...

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PMID: 20093773
DOI: 10.1172/jci38030

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