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Article

Acute myeloid leukemia fusion proteins deregulate genes involved in stem cell maintenance and DNA repair.

The Journal of clinical investigation - 1 Dec 2003

Alcalay Myriam, Meani Natalia, Gelmetti Vania, Fantozzi Anna, Fagioli Marta, Orleth Annette, Riganelli Daniela, Sebastiani Carla, Cappelli Enrico, Casciari Cristina, Sciurpi Maria Teresa, Mariano Angela Rosa, Minardi Simone Paolo, Luzi Lucilla, Muller Heiko, Di Fiore Pier Paolo, Frosina Guido, Pelicci Pier Giuseppe

Abstract excerpt

Acute myelogenous leukemias (AMLs) are genetically heterogeneous and characterized by chromosomal rearrangements that produce fusion proteins with aberrant transcriptional regulatory activities. Expression of AML fusion proteins in transgenic mice increases the risk of myeloid leukemias, suggesti...

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Source

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Identifiers

PMID: 14660751
DOI: 10.1172/JCI17595
PMCID: PMC281638

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14660751-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Acute myeloid leukemia fusion proteins deregulate genes involved in stem cell maintenance and DNA repair.PMID 14660751Read ↗

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