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Article

MLL oncoprotein levels influence leukemia lineage identities.

Nature communications - 29 Oct 2024

Janssens Derek H, Duran Melodie, Otto Dominik J, Wu Weifang, Xu Yiling, Kirkey Danielle, Mullighan Charles G, Yi Joanna S, Meshinchi Soheil, Sarthy Jay F, Ahmad Kami, Henikoff Steven

Abstract excerpt

Chromosomal translocations involving the mixed-lineage leukemia (MLL) locus generate potent oncogenic fusion proteins (oncoproteins) that disrupt regulation of developmental gene expression. By profiling the oncoprotein-target sites of 36 broadly representative MLL-rearranged leukemia samples, including three samples that underwent a lymphoid-to-myeloid lineage-switching event in response to therapy, we find the...

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Share to Cell Lineage
Share to Gene Expression Regulation, Leukemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hematopoietic Stem Cells

Share to Histone-Lysine N-Methyltransferase

Share to Myeloid-Lymphoid Leukemia Protein

Share to Oncogene Proteins, Fusion

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Translocation, Genetic

Source

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Identifiers

PMID: 39472576
DOI: 10.1038/s41467-024-53399-8
PMCID: PMC11522475

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