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Clinical and molecular consequences of fusion genes in myeloid malignancies

3 Aug 2020

Abstract excerpt

Leukemias are heterogeneous diseases characterized by aberrant hematopoietic stem and progenitor cells (HSPCs). Oncogenic fusion genes and proteins, produced via gross chromosomal rearrangements, such as chromosomal translocation, insertion, and inversion, play important roles in hematologic malignancies. These oncoproteins alter fundamental cellular properties, such as self-renewal, differentiation, and...

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PMID: 32745287
DOI: 10.1002/stem.3263

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