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Article

Retromer regulates postendocytic sorting of β-secretase in polarized Madin-Darby canine kidney cells.

Traffic (Copenhagen, Denmark) - 1 Oct 2012

Cuartero Yasmina, Mellado Maravillas, Capell Anja, Alvarez-Dolado Manuel, Verges Marcel

Abstract excerpt

β-Amyloid (Aβ) peptides are generated from the successive proteolytic processing of the amyloid precursor protein (APP) by the β-APP cleaving enzyme (BACE or β-secretase) and the γ-secretase complex. Initial cleavage of APP by BACE leads into the amyloidogenic pathway, causing or exacerbating Alzheimer's disease. Therefore, their intracellular traffic can determine how easily and frequently BACE has access to and...

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Source

Identifiers

PMID: 22758778
DOI: 10.1111/j.1600-0854.2012.01392.x

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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