Article

γ-secretase facilitates retromer-mediated retrograde transport

2024-06-07

Abstract excerpt

The retromer complex mediates retrograde transport of protein cargos from endosomes to the trans-Golgi network (TGN). γ-secretase is a multisubunit protease that cleaves the transmembrane domain of its target proteins. Mutations in genes encoding subunits of retromer or γ-secretase can cause familial Alzheimer disease (AD) and other degenerative neurological diseases. It has been reported that retromer interacts w...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b9e6314c-677c-5611-8ba6-c81143a0e459
DOI: 10.1101/2024.06.07.597932

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

γ-secretase facilitates retromer-mediated retrograde transportDOI 10.1101/2024.06.07.597932Read

Retromer regulates postendocytic sorting of β-secretase in polarized Madin-Darby canine kidney cells.Semantic proximity Read

Retromer disruption promotes amyloidogenic APP processing.Semantic proximity Read

Papillomavirus Infection Requires γ SecretaseSemantic proximity Read

Mistargeting of secretory cargo in retromer-deficient cells.Semantic proximity Read

Mistargeting of secretory cargo in retromer-deficient cellsSemantic proximity Read

Trafficking and proteolytic processing of APP.Semantic proximity Read

Protein sorting motifs in the cytoplasmic tail of SorCS1 control generation of Alzheimer's amyloid-β peptide.Semantic proximity Read

Dominant negative effect of the loss-of-function γ-secretase mutants on the wild-type enzyme through heterooligomerization.Semantic proximity Read

Adaptor protein 2-mediated endocytosis of the β-secretase BACE1 is dispensable for amyloid precursor protein processing.Semantic proximity Read

Retromer's Role in Endosomal Trafficking and Impaired Function in Neurodegenerative Diseases.Semantic proximity Read

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.Semantic proximity Read

The Retromer Supports AMPA Receptor Trafficking During LTP.Semantic proximity Read