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Article

CUG-binding protein represses translation of p27Kip1 mRNA through its internal ribosomal entry site

1 May 2011

Abstract excerpt

The cyclin dependent kinase inhibitor p27 (Kip1) plays an important role in controlling the eukaryotic cell cycle. The 5'-untranslated region of the p27 mRNA harbors an internal ribosome entry site (IRES) which may facilitate synthesis of p27 in certain conditions. In this study, the RNA-associated protein CUGBP1 was shown to interact with the human p27 5'-untranslated region. Overexpression of CUGBP1 inhibited...

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PMID: 21508681
DOI: 10.4161/rna.8.3.14804

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