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RNA CUG Repeats Sequester CUGBP1 and Alter Protein Levels and Activity of CUGBP1

1 Mar 2001

Abstract excerpt

An RNA CUG triplet repeat binding protein, CUGBP1, regulates splicing and translation of various RNAs. Expansion of RNA CUG repeats in the 3'-untranslated repeat of the mutant myotonin protein kinase (DMPK) mRNA in myotonic dystrophy (DM) is associated with alterations in binding activity of CUGBP1. To investigate whether CUGBP1 is directly affected by expansion of CUG repeats in DM tissues, we examined the...

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PMID: 11124939
DOI: 10.1074/jbc.m005960200

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Related research

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RNA CUG Repeats Sequester CUGBP1 and Alter Protein Levels and Activity of CUGBP1PMID 11124939Read ↗

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