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Article

Cellular mRNA recruits the ribosome via eIF3-PABP bridge to initiate internal translation

1 Feb 2016

Abstract excerpt

IRES-mediated translation of key cell fate regulating genes has been implicated in tumorigenesis. Concerted action of canonical eukaryotic initiation factors and IRES transacting factors (ITAFs) was shown to regulate cellular IRES mediated translation; however, the precise molecular mechanism of ribosome recruitment to cellular IRESes remains unclear. Here we show that the X-linked inhibitor of apoptosis (XIAP)...

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PMID: 26828225
DOI: 10.1080/15476286.2015.1137419

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