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Article

PCBP1 depletion promotes tumorigenesis through attenuation of p27Kip1 mRNA stability and translation

7 Aug 2018

Abstract excerpt

BACKGROUND: Poly C Binding Protein 1 (PCBP1) is an RNA-binding protein that binds and regulates translational activity of subsets of cellular mRNAs. Depletion of PCBP1 is implicated in various carcinomas, but the underlying mechanism in tumorigenesis remains elusive. METHODS: We performed a transcriptome-wide screen to identify novel bounding mRNA of PCBP1. The bind regions between PCBP1 with target mRNA were...

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PMID: 30086790
DOI: 10.1186/s13046-018-0840-1

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