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Article

Mutant p27(Kip1) and its potential effect as hepatocellular gene therapy.

Archives of medical research - 1 Aug 2008

Lu Mudan, Fei Min, Cheng Chun, Wang You, He Song, Zhao Yueming, Gao Shangfeng, Ke Qing, Li Peng, Cui Xiaopeng, Shen Aiguo

Abstract excerpt

BACKGROUND: The cyclin-dependent kinase (cdk) inhibitor p27(Kip1) is an important regulator of cell cycle progression as it negatively regulates G(0/1) progression and plays a major role in controlling the cell cycle. The screening of the p27(Kip1) sequence identified many potential phosphorylation sites. To investigate the effects of the overexpression of exogenous p27(Kip1) protein lacking the Thr157 sites on...

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Share to Carcinoma, Hepatocellular
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18662588
DOI: 10.1016/j.arcmed.2008.05.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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