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Article

Cell cycle-dependent translation of p27 involves a responsive element in its 5'-UTR that overlaps with a uORF

1 Jul 2003

Abstract excerpt

p27(Kip1) regulates cell proliferation by binding to and modulating the activity of cyclin-dependent kinases. The CDK inhibitor is haploinsufficient for tumor suppression and reduced p27 activity is fundamental for the development of many human malignancies. Consistently, reduced p27 protein provides independent prognostic information in various tumors including breast, prostate, colon and gastric carcinomas. In...

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PMID: 12837699
DOI: 10.1093/hmg/ddg177

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