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Article

A novel function of cIAP1 as a mediator of CHIP-driven eIF4E regulation.

Scientific reports - 29 Aug 2017

Seo Tae Woong, Lee Ji Sun, Choi Ye Na, Jeong Dar Heum, Lee Sun Kyung, Yoo Soon Ji

Abstract excerpt

eIF4E is an initiator protein in cap-dependent translation. Its overexpression is linked to tumorigenesis in various human cancers, suggesting that the levels of eIF4E must be under tight control in normal cells. Although several eIF4E regulatory mechanisms have been demonstrated, the intracellular mechanisms controlling eIF4E protein levels remain poorly understood. Here, we report that eIF4E is efficiently...

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Identifiers

PMID: 28852129
DOI: 10.1038/s41598-017-10358-2
PMCID: PMC5575267

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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