Article
Identification of critical residues in G(alpha)13 for stimulation of p115RhoGEF activity and the structure of the G(alpha)13-p115RhoGEF regulator of G protein signaling homology (RH) domain complex.
The Journal of biological chemistry - 10 Jun 2011
Hajicek Nicole, Kukimoto-Niino Mutsuko, Mishima-Tsumagari Chiemi, Chow Christina R, Shirouzu Mikako, Terada Takaho, Patel Maulik, Yokoyama Shigeyuki, Kozasa Tohru
Abstract excerpt
RH-RhoGEFs are a family of guanine nucleotide exchange factors that contain a regulator of G protein signaling homology (RH) domain. The heterotrimeric G protein Gα(13) stimulates the guanine nucleotide exchange factor (GEF) activity of RH-RhoGEFs, leading to activation of RhoA. The mechanism by which Gα(13) stimulates the GEF activity of RH-RhoGEFs, such as p115RhoGEF, has not yet been fully elucidated. Here,...
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