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Article

Gα12 structural determinants of Hsp90 interaction are necessary for serum response element-mediated transcriptional activation.

Molecular pharmacology - 1 Apr 2014

Montgomery Ellyn R, Temple Brenda R S, Peters Kimberly A, Tolbert Caitlin E, Booker Brandon K, Martin Joseph W, Hamilton Tyler P, Tagliatela Alicia C, Smolski William C, Rogers Stephen L, Jones Alan M, Meigs Thomas E

Abstract excerpt

The G12/13 class of heterotrimeric G proteins, comprising the α-subunits Gα12 and Gα13, regulates multiple aspects of cellular behavior, including proliferation and cytoskeletal rearrangements. Although guanine nucleotide exchange factors for the monomeric G protein Rho (RhoGEFs) are well characterized as effectors of this G protein class, a variety of other downstream targets has been reported. To identify Gα12...

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Identifiers

PMID: 24435554
DOI: 10.1124/mol.113.088443
PMCID: PMC3965892

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Gα12 structural determinants of Hsp90 interaction are necessary for serum response element-mediated transcriptional activation.PMID 24435554Read ↗

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