Article
Characterization of G alpha 13-dependent plasma membrane recruitment of p115RhoGEF.
The Biochemical journal - 1 May 2003
Bhattacharyya Raja, Wedegaertner Philip B
Abstract excerpt
The Ras homology (Rho) guanine nucleotide exchange factor (GEF), p115RhoGEF, provides a direct link between the G-protein alpha subunit, alpha(13), and the small GTPase Rho. In the present study, we demonstrate that activated mutants of alpha(13) or alpha(12), but not alpha(q), promote the redistribution of p115RhoGEF from the cytoplasm to the plasma membrane (PM). We also show that the PM translocation of...
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