Article
Activation of Jun kinase/stress-activated protein kinase by GTPase-deficient mutants of G alpha 12 and G alpha 13.
The Journal of biological chemistry - 4 Aug 1995
Prasad M V, Dermott J M, Heasley L E, Johnson G L, Dhanasekaran N
Abstract excerpt
Signal transduction pathways regulated by G12 and G13 heterotrimeric G proteins are largely unknown. Expression of activated, GTPase-deficient mutants of alpha 12 and alpha 13 alter physiological responses such as Na+/H+ exchanger activity, but the effector pathways controlling these responses have not been defined. We have found that the expression of GTPase-deficient mutants of alpha 12 (alpha 12Q229L) or alpha...
Topics
- 3T3 Cells
- Animals
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Line
- Chlorocebus aethiops
- Enzyme Activation
- GTP Phosphohydrolases
- GTP-Binding Proteins
- JNK Mitogen-Activated Protein Kinases
- Mice