Article
Toxicogenomics of nevirapine-associated cutaneous and hepatic adverse events among populations of African, Asian, and European descent.
AIDS (London, England) - 19 Jun 2011
Yuan Jing, Guo Sheng, Hall David, Cammett Anna M, Jayadev Supriya, Distel Manuel, Storfer Stephen, Huang Zimei, Mootsikapun Piroon, Ruxrungtham Kiat, Podzamczer Daniel, Haas David W
Abstract excerpt
OBJECTIVE: Nevirapine is widely prescribed for HIV-1 infection. We characterized relationships between nevirapine-associated cutaneous and hepatic adverse events and genetic variants among HIV-infected adults. DESIGN: We retrospectively identified cases and controls. Cases experienced symptomatic nevirapine-associated severe (grade III/IV) cutaneous and/or hepatic adverse events within 8 weeks of initiating...
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