Genome-wide association study of nevirapine hypersensitivity in a sub-Saharan African HIV-infected population.

doi:10.1093/jac/dkw545

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Article

Genome-wide association study of nevirapine hypersensitivity in a sub-Saharan African HIV-infected population.

The Journal of antimicrobial chemotherapy - 1 Apr 2017

Carr Daniel F, Bourgeois Stephane, Chaponda Mas, Takeshita Louise Y, Morris Andrew P, Castro Elena M Cornejo, Alfirevic Ana, Jones Andrew R, Rigden Daniel J, Haldenby Sam, Khoo Saye, Lalloo David G, Heyderman Robert S, Dandara Collet, Kampira Elizabeth, van Oosterhout Joep J, Ssali Francis, Munderi Paula, Novelli Giuseppe, Borgiani Paola, Nelson Matthew R, Holden Arthur, Deloukas Panos, Pirmohamed Munir

Abstract excerpt

Background: The antiretroviral nevirapine is associated with hypersensitivity reactions in 6%-10% of patients, including hepatotoxicity, maculopapular exanthema, Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Objectives: To undertake a genome-wide association study (GWAS) to identify genetic predisposing factors for the different clinical phenotypes associated with nevirapine...

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PMID: 28062682
DOI: 10.1093/jac/dkw545
PMCID: PMC5400091

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ERAP2
ERAP1

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