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Article

HLA Class I restricted CD8+ and Class II restricted CD4+ T cells are implicated in the pathogenesis of nevirapine hypersensitivity

6 Jun 2014

Abstract excerpt

OBJECTIVES: This study sought to examine nevirapine hypersensitivity (NVP HSR) phenotypes and their relationship with differing major histocompatibility complex (MHC) Class I and Class II alleles and the associated CD4 and CD8 T-cell NVP-specific responses and their durability over time. METHODS: A retrospective cohort study compared HIV-positive patients with NVP HSR, defined by fever and hepatitis and/or rash,...

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PMID: 24911354
DOI: 10.1097/qad.0000000000000345

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