Article
Pharmacogenetics of nevirapine-associated hepatotoxicity: an Adult AIDS Clinical Trials Group collaboration.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 15 Sept 2006
Haas David W, Bartlett John A, Andersen Janet W, Sanne Ian, Wilkinson Grant R, Hinkle John, Rousseau Franck, Ingram Christiana D, Shaw Audrey, Lederman Michael M, Kim Richard B
Abstract excerpt
Associations have been reported between an MDR1 variant and responses to nonnucleoside reverse-transcriptase inhibitors. We explored associations between MDR1, CYP2B6, and CYP3A polymorphisms and nevirapine hepatotoxicity. Among participants in a randomized study in South Africa (FTC-302), MDR1 3435C-->T was significantly associated with decreased risk of hepatotoxicity (risk ratio, 0.30; P=.016).
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