Article
CYP2B6 c.983T>C polymorphism is associated with nevirapine hypersensitivity in Malawian and Ugandan HIV populations.
The Journal of antimicrobial chemotherapy - 1 Dec 2014
Carr Daniel F, Chaponda Mas, Cornejo Castro Elena M, Jorgensen Andrea L, Khoo Saye, Van Oosterhout Joep J, Dandara Collet, Kampira Elizabeth, Ssali Francis, Munderi Paula, Lalloo David G, Heyderman Robert S, Pirmohamed Munir
Abstract excerpt
BACKGROUND: Nevirapine, an NNRTI used in HIV treatment, can cause hypersensitivity reactions in 6%-10% of patients. In the most serious cases (1.3%) this can manifest as Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN). METHODS: DNA samples were obtained and analysed from a total of 209 adult patients with nevirapine hypersensitivity (57 from a prospective cohort and 152 routine clinic patients)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.