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Article

Genetics of Nevirapine Metabolic Pathways at Steady State in HIV-Infected Cambodians.

Antimicrobial agents and chemotherapy - 1 Dec 2017

Eloy Philippine, Tessier Adrien, Fan-Havard Patty, Chou Monidarin, Verstuyft Céline, Taburet Anne-Marie, Haas David W, Bertrand Julie

Abstract excerpt

Nevirapine is metabolized by several hepatic cytochrome P450 (CYP) isoforms to generate four primary hydroxylated metabolites: 2-hydroxynevirapine, 3-hydroxynevirapine, 8-hydroxynevirapine, and 12-hydroxynevirapine. The present study characterized associations between genetic polymorphisms and metabolite ratios in HIV-infected Cambodians. We demonstrate associations between CYP2B6 polymorphisms and metabolite...

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Identifiers

PMID: 28947469
DOI: 10.1128/AAC.00733-17
PMCID: PMC5700353

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